The effect of red Turi leaf extract (Sesbania glandiflora L.Pers) on the reduced levels of TNF-α, IL-1β and the number of bacterial colonies on the puerperium Mus Musculus ovarian inoculated by Staphylococcus aureus

Staphylococcus aureus is one of the bacteria that causes postpartum infection, where this bacterium releases peptidoglycans and lipoteichoic acid (LTA) start inflammation response, which then responded by macrophages releasing pro-inflammation cytokines such as Tumor Necrosis Factor-Alpha (TNF-α) Interleukin 1-Beta (IL-1β). Red Turi leaf extract, known to contain saponins, flavonoids, tannins work suppressing growth forcing bacterial cells undergo lysis, causing reduction immune system activation results in secretion TNF-α IL-1β. This research aims analyze effect red extract reducing TNF-α, IL-1β, colonies on puerperium Mus Musculus Ovarian Inoculated aureus. Results study proved doses 125, 250, 500 mg/kgBW/day was able reduce number The optimum were 250 mg/kgBW/day. Thus, infection caused intravaginal inoculation for 24 hours Ovary alleviated treatment with